The idea of being able to turn back the clock is appealing, but it’s important to note that anti-aging is not as simple as keeping your wrinkles down or putting a little spring in your step. Instead, it’s a complex process. As a result, taking aging down from the cellular level means many effects, including:
- Refine cognitive functionality
- Enrich muscle and joint strength
- Reverse the effects of aging
- Repair damaged muscles
- Maintain damaged organs
- Repair injured skin
- Help in repairing any damage caused to the brain
- Improve the quality of sleep
- Help in improving stamina1
That’s quite a lot to promise, but to understand how this happens, we need to take a closer look at Niagen and how it does its work.
Niagen And Aging
Niagen, also known as nicotinamide riboside, is a natural version of vitamin B3 found in milk as a trace element. Up until now, it was considered too difficult or expensive to mass produce. Now, with Chromadex creating Niagen, everyone can take advantage of its benefits. We know that vitamin B3 supports many different health functions, but Niagen is special, especially when it comes to aging.2
What separates Niagen from other forms of Vitamin B3 is that it supports levels of NAD+. (nicotinamide adenine dinucleotide). This co-enzyme is a central block of our cellular function, helping mitochondria and the nucleus communicate. However, we produce less and less of it as we age. When it gets to low levels, this can lead to a variety of issues, like:
- Increased sunburn
- Increased visceral fat storage (increased belly fat)
- Increased blood sugar levels and metabolic syndrome
- Worsening cardiovascular diseases
- Increased fat storage in the liver
- Other effects of aging and health conditions
Proving Niagen Right
Science on aging is still in its infancy, but what there is so far is promising. The research, reported in the journal Nature Communications, led by Charles Brenner, Ph.D., professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine in collaboration with colleagues at Queens University Belfast and ChromaDex Corp. which supplied Niagen for the trial.
Six men and six women, all healthy, took part in the trial. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR. This took place in different sequences with a seven-day gap between doses. Following each dose, blood and urine samples were collected and analyzed to show measured levels of a cell metabolite—known as NAD+. As levels of NAD+ decrease with age, some believe that they may play a role in cell decline.
The end results showed that using nicotinamide riboside increased NAD+ metabolism by amounts directly related to the dose. In addition, there were no major side effects.
“This trial shows that oral NR safely boosts human NAD+ metabolism,” Brenner says. “We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears that health benefits of NR will be translatable to humans safely.” Brenner also ran a smaller trial on himself. He found similar results.3
Other studies on Niagen in other products have shown positive effects on NAD+ levels. One larger study in elderly people showed that a single 250 mg dose of Niagen increased blood NAD+ levels by 40%. These elevated levels were maintained throughout the 8 weeks of the trial. The findings showed that a sweet spot for Niagen supplementation was between 250-500 mg per day. However, there are some differences when it comes to this area.
There may be more to come here. A collaboration between Keio University School of Medicine in Tokyo and Washington University School of Medicine is going to be the first long-term clinical trial for Niagen in humans. This is going to be checking for:
- change in insulin sensitivity
- change in beta-cell function
- works to control blood sugar
- blood vessels dilate
- effects of NMN on blood lipids
- effects of NMN on body fat
- markers of cardiovascular and metabolic health4
Similar tests in rodents have shown positive results.
If you are looking to get started, note that dosage will vary based on weight and age. In general, the older and heavier you are, the more Niagen you will need to see results. One clinical study shows that there are no adverse effects at 300 mg/kg/day. Combine a doctor’s insight with Niagen and good lifestyle practices like staying active and eating well, and you stack the deck in your favor against aging.